In recent decades, clinical research, especially clinical trials, has been shown to improve: i) access to new health technologies and frontline scientific knowledge; ii) adoption of better clinical practices; iii) quality of generated data and analysis; iv) education level of the workforce; and v) creation of new jobs and alternative sources of funding for institutions and countries. The massive amounts of data produced by clinical research have become a valuable asset, which is expected to impact economic policies in the coming decades.
Constraints related to clinical research in Portugal were previously acknowledged and remain topical: lack of funding, financial incentives, adequate policies, and a solid strategy for clinical research.
In this article, we aim to evaluate the clinical trials panorama in Portugal regarding structures, procedures, and outcomes (Table 1) and describe possible solutions to the identified problems (Table 2).

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